United States securities and exchange commission logo November 15, 2022 David Southwell President and Chief Executive Officer TScan Therapeutics, Inc. 830 Winter Street Waltham, Massachusetts 02451 Re: TScan Therapeutics, Inc. Registration Statement on Form S-3 Filed November 9, 2022 File No. 333-268260 Dear David Southwell: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Tyler Howes at 202-551-3370 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: William D. Collins, Esq.