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Long-Term Debt Final Payment fee Plus: Final payment fee Accretion of marketable securities Accretion of Marketable Securities Accretion of marketable securities. Facility-Related and Other Facility Related and Other [Member] Facility related and other. Assets Assets [Abstract] Risk free interest rate Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Increase (Decrease) in Prepaid Expense and Other Assets, Total Prepaid expenses and other assets Increase (Decrease) in Prepaid Expense and Other Assets K2HV [Member] K2 Health Ventures. K2 Health Ventures [Member] Document Fiscal Year Focus Document Fiscal Year Focus Debt Conversion, Converted Instrument, Shares Issued Converted instrument, shares issued Cash flows from investing activities: Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract] Accounts Payable, Current, Total Accounts payable Accounts Payable, Current Interest expense Interest Expense, Long-Term Debt, Total Interest Expense, Long-Term Debt Interest expense Research and Development Research and Development Expense [Member] Fair Value, off-Balance-Sheet Risk [Table] Deferred revenue Deferred Revenue Deferred Revenue, Total Temporary Equity Disclosure [Abstract] Proceeds from exercise of stock options Proceeds from Stock Options Exercised Fair Value Disclosures [Abstract] Commitments and Contingencies Disclosure [Abstract] Debt Instrument [Axis] Share-Based Payment Arrangement [Abstract] Assets, Fair Value Disclosure Total financial assets Sale of Stock Sale of Stock [Axis] Cash Provided by (Used in) Investing Activity, Including Discontinued Operation Net cash provided by (used in) investing activities Laboratory Supplies Research Materials And Studies [Member] Laboratory Supplies Research Materials And Studies. Laboratory Supplies, Research Materials and Studies Fair value, assets, transfers into level 3 Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Transfers Into Level 3 Title of 12(b) Security Title of 12(b) Security Schedule of Segment Reporting Information, by Segment [Table] Money Market Funds Money Market Funds [Member] Cash Equivalents - Money Market Funds Related and Nonrelated Parties [Domain] Document Information [Table] Document Information [Table] Other Liabilities, Noncurrent, Total Other long term liabilities Other Liabilities, Noncurrent Changes in current assets and liabilities: Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract] Stock Options Outstanding, Weighted Average Exercise Price, Beginning Balance Stock Options Outstanding, Weighted Average Exercise Price, Ending balance Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Convertible Preferred Stock Preferred Stock [Text Block] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Fair Value, Recurring and Nonrecurring [Table] Additional Paid-In Capital Additional Paid-in Capital [Member] Accrued expense and other liabilities Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Statement of Income Location, Balance [Axis] Income Statement Location Trading Symbol Trading Symbol Prepayment fee range Percentage of Loan Prepayment Fee Range Percentage of Loan Prepayment Fee Range Prepayment fee range Subsequent Event Type [Axis] Commitments And Contingencies Disclosure [Table] Commitments And Contingencies Disclosure [Table] Commitments and contingencies disclosure. 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License upfront payment receivable Upfront payment receivable Common stock price per warrant. Common Stock Price Per Warrant Common stock price per warrant Underwriter option to purchase number of additional shares. Underwriter Option To Purchase Number Of Additional Shares Underwriter option to purchase number of additional shares Novartis Novartis [Member] Novartis. Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] Comprehensive loss: Stock-Based Compensation Stock Based Compensation [Member] Stock-based compensation. Summary of Basic and Diluted Net Loss Per Share Schedule of Weighted Average Number of Shares [Table Text Block] Expected volatility of underlying common stock Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate Preferred stock, shares authorized Preferred Stock, Shares Authorized Entity Registrant Name Entity Registrant Name Loan and Security Agreements Debt Disclosure [Text Block] Loan and Security Agreements Purchase price of restricted common stock Share Based Compensation Arrangement By Share Based Payment Award Purchase Price Of Restricted Common Stock Share based compensation arrangement by share based payment award purchase price of restricted common stock. Total other income Other Nonoperating Income (Expense) Proceeds from issuance of common stock, net of offering costs Proceeds from Issuance of Common Stock Proceeds from issuance of common stock, net of offering costs Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated Other Comprehensive Income (Loss), Net of Tax, Total Accumulated other comprehensive loss Interest only payment extended term. Interest Only Payment Extended Term Interest only payment extended term Payments to Acquire Property, Plant, and Equipment, Total Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Temporary Equity By Class Of Stock [Table] Temporary Equity, by Class of Stock [Table] Total assets Assets Stock options exercisable, Weighted Average Remaining Contractual Life Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Income Statement [Abstract] Non Rule 10b 51 Arr Modified Flag Non Rule 10b 51 Arr Modified Flag. Non-Rule 10b5-1 Arrangement Modified Expects research term Expects Research Term Expects research term. License upfront payment. License Upfront Payment Upfront payment Stock Issued During Period, Shares, New Issues Number of shares issued Issuance of common stock, net of offering costs, shares Preferred Stock Authorized Temporary Equity, Shares Authorized Unvested restricted stock, Vested Unvested restricted stock, Vested Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Net loss per share, diluted Net loss per share, diluted Earnings Per Share, Diluted Earnings Per Share, Diluted, Total Convertible outstanding principal balance Debt Conversion, Original Debt, Amount Schedule of Segment Information Schedule of Segment Reporting Information, by Segment [Table Text Block] City Area Code City Area Code Debt Instrument, Face Amount Principal amount Line of Credit Facility, Maximum Borrowing Capacity Principal amount Counterparty Name Counterparty Name [Domain] Collaboration and license agreements. Collaboration And License Agreements [Table] Collaboration And License Agreements [Table] Issuance of common stock under ESPP plan Stock Issued During Period, Value, Employee Stock Purchase Plan Segment Reporting Information [Line Items] Rule 10b 51 Arr Modified Flag Rule 10b 51 Arr Modified Flag. 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Entity Interactive Data Current Entity Interactive Data Current Deferred revenue Increase (Decrease) in Contract with Customer, Liability Income Statement Location Statement of Income Location, Balance [Domain] Cash flows from operating activities: Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract] Common Stock Issuable Upon Conversion Convertible Preferred Stock, Shares Issued upon Conversion Common stock issuable upon conversion Entity Tax Identification Number Entity Tax Identification Number Revenue Revenues [Abstract] Noncash Interest Expense On Notes Payable Noncash interest expense on notes payable. Non-cash interest expense related to note payable Local Phone Number Local Phone Number Unrecognized stock-based compensation expense Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount Royalty Agreement Royalty Agreement Terms [Member] Payments of Financing Costs Payments of Financing Costs, Total Cash paid for financing costs Accounting Policies [Abstract] Revenue from Contract with Customer, Excluding Assessed Tax, Total Collaboration and license revenue Revenue from Contract with Customer, Excluding Assessed Tax Issuance of common stock upon exercise of pre-funded warrants Stock Issued During Period Shares Exercise Of Pre funded Warrants Value Stock Issued During Period Shares Exercise Of Pre funded Warrants Value. Jason Amello [Member] Jason Amello. Final fee Final Fee Percentage Final Fee Percentage Final fee Class of Stock Class of Stock [Domain] Shares available for future grant Number of awards permitted to grant Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Weighted average period remaining (in years) Accrued consulting and professional services Accrued Professional Fees, Current Schedule of Accrued Expenses and Other Current Liabilities Schedule of Accounts Payable and Accrued Liabilities [Table Text Block] Stock, Class of Stock [Table] Entity Emerging Growth Company Entity Emerging Growth Company Stock Options vested or expected to vest, Weighted Average Remaining Contractual Life Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term 2018 Equity Incentive Plan Two Thousand And Eighteen Equity Incentive Plan [Member] 2018 equity incentive plan. Collaboration And License Revenue Collaboration and license revenue.